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Over-prescription of needless antibiotics is fuelling the rising tide of antimicrobial resistance that threatens to render current antibiotics ineffective. We propose a rapid, highly-compact, non-specialist operator and low-cost device for use in primary healthcare, enabling GPs to immediately diagnose bacterial infections and their antibiotic susceptibility. This will lead to a step-change improvement in informed, targeted prescriptions; saving lives, money and time, as well as slowing resistance. Our technology uniquely brings together nanophotonic waveguides and microfluidics to determine the response of bacteria to minute quantities of antibiotics. In this Phase 1 proposal we will demonstrate proof-of-principle, working closely with GP end-users.

The project will deliver a novel aid for use in triage to support early and accurate diagnosis of Parkinsons disease (PD). The PD Pen could radically change the way patients are screened and referred to specialists by leveraging at GP level of care to create greater efficiency in utilization of specialty centers; make the process more convenient for patients and speed up access to specialists when needed. The Pen can also be used in disease monitoring - crucial along with timely diagnosis - to keep patients well and establish cost savings through optimising treatment. The accuracy of prototype clinical validation was 80%.

There are approximately 123,000 cases of sepsis per year in England and around 36,800 associated deaths - of which 70% of cases come from the community. Medtechtomarket Consulting Ltd have demonstrated a proof of concept (patent filed) for a novel, highly sensitive, simple and low cost test for the early diagnosis and subsequent therapy monitoring of Sepsis. This project proposal focuses on performance feasibility studies, and establishing a clinical advisory panel. The vision is that GPs will be able to test for sepsis much sooner and more often, reducing uncertainty and allowing treatment to start in the critical early stages.